ea0013oc34 | British Thyroid Association Award | SFEBES2007
James Sally
, McCabe Christopher
, Reaves Barbara
, Smith Vicki
, Chan Shiao
, Barrett Timothy
, Kilby Mark
, Franklyn Jayne
Thyroid hormones play vital roles in fetal brain development. Mutations in MCT8, recently recognised as a specific thyroid hormone transporter, define a novel syndrome of severe X-linked psychomotor retardation and thyroid hormone resistance.N-TERA-2 (NT2) cells (human embryonal cells with characteristics of CNS precursors) were transiently transfected with either WT MCT8 or its L471P, R271H or S448X mutations, described in males affected by severe psych...